CADgene: Coronary Artery Disease Gene Database

Coronary artery disease (CAD) or coronary heart disease (CHD) is the leading cause of death worldwide. CAD is caused by the buildup of plaque on the inside of the coronary arteries that supply the heart muscle with oxygen and nutrients. CAD is a complex disease influenced by multiple combinations of gene-gene and gene-environment interactions. The widely used strategy to identify susceptibility genes is case-control study that looks for associations between phenotype and genotype. Until now, many genomic regions and many variants in many genes were implicated as markers of greater susceptibility to develop CAD. However many of these results were poorly replicated.

Here we constructed the Coronary Artery Disease Gene Database (CADgene) which consists of information of the comprehensive CAD related genes from literature. The aim of CADgene is to provide a useful gene resource to the research community of cardiovascular disease, especially coronary artery disease. Currently, the CADgene database contains more than 300 CAD related genes and their detailed information associated with CAD from about 2000 publications.

Publication for more information and for citing this work:
CADgene: a comprehensive database for coronary artery disease genes
Hui Liu; Wei Liu; Yifang Liao; Long Cheng; Qian Liu; Xiang Ren; Lisong Shi; Xin Tu; Qing Kenneth Wang^*; An-Yuan Guo^*
Nucleic Acids Research 2011; 39:D991-6.

Users can browse or search the database in different levels.

Browse by Functional Category


Endothelial integrity	Gender difference	Homocysteine metabolism	Immune and inflammation	Lipid and lipoprotein metabolism	Metalloproteinase and ECM


Oxidation-reduction state	Rennin-angiotensin system	Glucose metabolism	Thrombosis	Vascular smooth muscle cell abnormalities	Others

Browse by Chromosome

Click here to browse all genes.

Click here to browse all SNPs.