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    Coronary artery disease (CAD) or coronary heart disease (CHD) is the leading cause of death worldwide and it is a complex disease influenced by multiple combinations of gene-gene and gene-environment interactions. Until now, many genomic regions and many variants in many genes were implicated as markers of greater susceptibility to develop CAD. To provide a useful and comprehensive gene resource of CAD, we constructed the Coronary Artery Disease Gene Database (CADgene) that was published in the 2011 NAR database issue.
 
    Here CADgene was updated to the second version CADgene V2.0, and we did not only double the gene information related to CAD using scientific papers published in the last 3 years, but we also added many useful results and features on the database webpage. These features are: 1) graphics showing the network community data among the currently collected candidate genes; 2) a gene network and network community detection tool; 3) a SNP alias search function and graphic displays of the distribution of CAD-associated SNPs on each gene. In addition, 12 recently published CAD related GWAS studies were updated into CADgene V2.0. Currently, the database contains more than 600 CAD related genes and detailed information associated with CAD from about 5000 publications.

Users can browse or search the database in different levels. And for better visual effects, it is recommended to use browsers like google chrome´╝îfire fox or other higher version browers.

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Endothelial integrity Gender difference Homocysteine metabolism Immune and inflammation Lipid and lipoprotein metabolism Metalloproteinase and ECM
Endothelial integrity Gender difference Homocysteine metabolism Immune and inflammation Lipid and lipoprotein metabolism Metalloproteinase and ECM
 
Oxidation-reduction state Rennin-angiotensin system Glucose metabolism Thrombosis Vascular smooth muscle cell abnormalities Others
Oxidation-reduction state Rennin-angiotensin system Glucose metabolism Thrombosis Vascular smooth muscle cell abnormalities Others

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Publication for more information and for citing this work:
CADgene: a comprehensive database for coronary artery disease genes
Hui Liu; Wei Liu; Yifang Liao; Long Cheng; Qian Liu; Xiang Ren; Lisong Shi; Xin Tu; Qing Kenneth Wang*; An-Yuan Guo*
Nucleic Acids Research 2010; doi: 10.1093/nar/gkq1106

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